Investigation of the PtdIns(4,5)P2 dependence of plasma membrane receptor endocytosis in living cells
نویسندگان
چکیده
Background Phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2) plays an important role in various cellular processes: not only in calcium signalling as a precursor for the second messenger Ins(1,4,5)P3, but also in the regulation of ion channels, cytoskeletal dynamics and many other events connected to the plasma membrane. Since many of the molecules participating in the process of endocytosis can bind PtdIns(4,5)P2, a role of this lipid in the regulation of the internalization of plasma membrane receptors seemed possible.
منابع مشابه
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عنوان ژورنال:
دوره 9 شماره
صفحات -
تاریخ انتشار 2009